Children:
- Jane Lupo was born Abt 10 Jun 1571, St Botolph's Aldgate, London, England; was christened 10 Jun 1571, St Botolph without Aldgate Church, London, England; died Abt 28 Mar 1583, St Botolph's Aldgate, London, England; was buried 30 Mar 1583, St Botolph's Aldgate, London, England.
- Katherine Lupo was born 29 Sep 1575, St Botolph's Aldgate, London, England; died Abt 11 Oct 1575, St Botolph's Aldgate, London, England; was buried 11 Oct 1575, St Botolph's Aldgate, London, England.
- Thomas Lupo was born Abt 7 Jun 1577, St Botolph's Aldgate, London, England; was christened 7 Jun 1577, St Botolph without Aldgate Church, London, England; died 1642.
- Lt. Albiano Lupo was born Abt 22 Aug 1579, St Botolph's Aldgate, London, England; was christened 22 Aug 1579, St Botolph without Aldgate Church, London, England; died Bef 9 Oct 1626, Elizabeth City, Virginia.
- Elizabeth Lupo was born Abt 16 Jun 1581, St Botolph's Aldgate, London, England; was christened 16 Jun 1581, St Botolph without Aldgate Church, London, England.
- 1. Phillip Lupo was born Abt 15 Jun 1582, St Botolph's Aldgate, London, England; was christened 15 Jun 1582, St Botolph without Aldgate Church, London, England; died 8 Feb 1668, Stepney, London, Middlesex, England.
- Ferdinando Lupo was born Abt 15 Sep 1585, St Botolph's Aldgate, London, England; was christened 15 Sep 1585, St Botolph without Aldgate Church, London, England; died 22 Feb 1623, Isle of Wight, Virginia, USA.
- Mary Lupo was born 1588, St Botolph's Aldgate, London, England.
- Katherine Lupo was born 9 Mar 1594, St Botolph's Aldgate, London, England.
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